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513024-M

Millipore

PD 151746

A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain.

Synonym(s):

PD 151746, 3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid

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About This Item

Empirical Formula (Hill Notation):
C11H8FNO2
CAS Number:
179461-52-0
Molecular Weight:
205.19
MDL number:
MFCD03453564
UNSPSC Code:
12352200

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

orange

solubility

DMSO: 200 mg/mL
methanol: 5 mg/mL

storage temp.

−20°C

InChI

1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-

InChI key

HWMQHECFXSVZGN-KMKOMSMNSA-N

General description

A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for µ-calpain (Calpain I) over m-calpain (Calpain II) (Ki values, 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide induced apoptosis.
A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for calpain-1 (Cat. Nos. 208712 and 208713) over calpain-2 (Cat. Nos. 208715 and 208718) (Ki values: 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide-induced apoptosis.

Biochem/physiol Actions

Primary Target
calpain-1
Target Ki: 260 nM against calpain-1

Warning

Toxicity: Standard Handling (A)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Other Notes

Squier, M.K., et al. 1999. J. Cell Physiol.178, 311.
Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 6687.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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