Myristoylated-FEEERA, mP6

A cell-permeable myristoylated hexapeptide derived from EXE-motif-containing integrin β3 subunit that selectively inhibits integrin outside-in signaling without affecting inside-out signaling . Shown to specifically block the interaction of Gα3 and integrin β3 subunit resulting in the inhibition of Gα13-dependent early phase outside-in signaling. Selectively inhibits thrombosis without affecting haemostasis.

A cell-permeable myristoylated hexapeptide derived from EXE-motif-containing integrin β3 subunit that selectively inhibits integrin outside-in signaling without affecting inside-out signaling . Shown to specifically block the interaction of Gα3 and integrin β3 subunit resulting in the inhibition of Gα13-dependent early phase outside-in signaling. Selectively inhibits thrombosis without affecting haemostasis.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Cell permeable: yes

Primary Target
platelet integrin →IIb→3

Reversible: yes

Packaged under inert gas

Toxicity: Standard Handling (A)

FEEERA

Following reconstitution, aliquot and freeze (-207deg;C). Stock solutions are stable for up to 3 months at -20°C.

Shen, B., et al. 2013. Nature503, 131.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany