All Photos(1)
Synonym(s):
Isradipine, L-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110
Empirical Formula (Hill Notation):
C19H21N3O5
Recommended Products
Assay
≥98% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
DMSO: 100 mM
ethanol: 50 mM
storage temp.
2-8°C
InChI
1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
InChI key
HMJIYCCIJYRONP-UHFFFAOYSA-N
General description
A water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC50 of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.
A water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC50 of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Primary Target
CaV
CaV
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Chan, C. S. et al. 2007. Nature.447, 1081.
Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci.45, 708.
Koschak, A. et al. 2003. J. Neurosci.23, 6041.
Koschak, A. et al. 2001. J. Biol Chem276, 22100.
Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci.45, 708.
Koschak, A. et al. 2003. J. Neurosci.23, 6041.
Koschak, A. et al. 2001. J. Biol Chem276, 22100.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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