All Photos(1)
Synonym(s):
Gabapentin, L-type Voltage Gated Ca2+ Channel Blocke, Gabapentin
Empirical Formula (Hill Notation):
C9H17NO2
Recommended Products
Assay
≥98% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
water: 100 mM
storage temp.
2-8°C
InChI
1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
InChI key
UGJMXCAKCUNAIE-UHFFFAOYSA-N
General description
A water soluble GABA analog originally developed to treat epilepsy and neuropathic pain but is not believed to act on the same brain receptors. Gabapentin interacts with voltage-gated calcium channels in cortical neurons. It binds to the α2δ subunit (1 and 2) and has been found to reduce calcium currents after chronic but not acute application via an effect on trafficking of voltage-dependent calcium channels in the central nervous system.
Biochem/physiol Actions
Primary Target
α2δ subunit of L-type voltage gated Ca2+ channels
α2δ subunit of L-type voltage gated Ca2+ channels
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Eroglu, C. et al. 2009. Cell.139, 380.
Hendrich, J. et al. 2008. Proc. Natl. Acad. Sci. USA105, 3628.
Davies, A. et al. 2007. Trends Pharmacol. Sci.28, 220.
Hendrich, J. et al. 2008. Proc. Natl. Acad. Sci. USA105, 3628.
Davies, A. et al. 2007. Trends Pharmacol. Sci.28, 220.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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