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Merck
CN

5.08505

A-803467

Synonym(s):

A-803467, Sodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467

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About This Item

Empirical Formula (Hill Notation):
C19H16ClNO4
CAS Number:
944261-79-4
Molecular Weight:
357.79
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
MFCD10574689
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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storage temp.

2-8°C

form

solid

InChI

1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)

InChI key

VHKBTPQDHDSBSP-UHFFFAOYSA-N

assay

≥98% (HPLC)

potency

8 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mM, ethanol: 25 mM

Quality Level

100

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General description

A voltage gated sodium channel type 1.8 (Nav1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC50) = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocked human Nav1.8 (IC50 = 8 nM) and was >100-fold selective vs. human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50 values ≥ 1 µM).

Biochem/physiol Actions

Primary Target
Nav1.8

Other Notes

Jarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA104, 8520.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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