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5.08161

Sigma-Aldrich

SNC80

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Synonym(s):
SNC80, δ Opioid Receptor Agonist, SNC80
Empirical Formula (Hill Notation):
C28H39N3O2
CAS Number:
156727-74-1
Molecular Weight:
449.63
MDL number:
MFCD00672673
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

Quality Level

100

form

solid

potency

0.32 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

cream

solubility

1 M HCl: 100 mM
DMSO: 20 mM

storage temp.

−20°C

InChI

1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1

InChI key

KQWVAUSXZDRQPZ-UMTXDNHDSA-N

General description

A very potent and selective δ opioid receptor agonist (IC50 = 0.32 µM). Shown to induce dose- and time-dependent antinociception after i.c.v., i.th. and i.p. administration in mice. Widely used in studies of depression and inflammatory injuries. It is also reported to be acted upon heteromeric u-d receptors.

Biochem/physiol Actions

Primary Target
Dela opioid receptor

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pradhan, A., et al., 2013. Mol Pain.9, 8.
Saitoh, A., et al., 2012. Curr. Neuropharmacol.10, 231.
Metcalf. M. et al. 2012. ACS Chem. Neurosci.3, 505.
Bilsky, J., et al. 1995. J. Pharmacol. Exp. Ther.273, 359.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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