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5.08159

Sigma-Aldrich

Salvinorin A

Synonym(s):

Salvinorin A, κ-opioid Receptor Agonist, Salvinorin A, Divinorin A

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About This Item

Empirical Formula (Hill Notation):
C23H28O8
CAS Number:
83729-01-5
Molecular Weight:
432.46
MDL number:
MFCD05664742
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

Quality Level

100

form

solid

potency

4.3 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

ethanol: 10 mM
DMSO: 50 mM

storage temp.

−70°C

InChI

1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1

InChI key

OBSYBRPAKCASQB-AGQYDFLVSA-N

General description

A highly potent and selective non-alkaloid positive allosteric modulator of Κ-opioid receptors (Ki = 4.3 nM and 16 nM for native and cloned κ-opioid receptors, respectively). Also acts as a D2DR partial agonist (Ki = 5-10 nM). Used in studies of addition.

Biochem/physiol Actions

Primary Target
k opioid receptor

Warning

Toxicity: Standard Handling (A)

Other Notes

Roth, B. et al., 2002. PNAS.99, 11934.
Valdés III., j., et al., 1984. J. Organic Chem.49, 4716.
Ortega, A., et al., 1982. J. of Chem. Society, Perkins Transactions I. 2505.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Information

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