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5.08146

Sigma-Aldrich

WAY-100635 Maleate

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Synonym(s):
WAY-100635 Maleate, 5-HT 1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635, 5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635
Empirical Formula (Hill Notation):
C25H34N4O2 · xC4H4O4
CAS Number:
634908-75-1
Molecular Weight:
422.56 (free base basis)
MDL number:
MFCD01321056
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥97% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

water: 50 mM

storage temp.

2-8°C

InChI

1S/C25H34N4O2.C4H4O4/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21;5-3(6)1-2-4(7)8/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

XIGAHNVCEFUYOV-BTJKTKAUSA-N

General description

A selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro.

Biochem/physiol Actions

Primary Target
5-HT1A

Warning

Toxicity: Standard Handling (A)

Preparation Note

Warming is required for complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hunt, G. E. et al. 2011. Brain Res. Bull.86, 65.

Caamano, R. I. et al. 2010. J. Exp. Biol.213, 1813.

Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol.357, 205.
Forster, E. A. et al. 1995. Eur. J. Pharmacol.281, 81.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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