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5.06236

Sigma-Aldrich

Tiagabine Hydrochloride

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Synonym(s):
Tiagabine Hydrochloride, GABA reuptake inhibitor, Tiagabine, Gabitril, GAT-1 GABA Transporter Inhibitor, Tiagabine
Empirical Formula (Hill Notation):
C20H25NO2S2 · xHCl
CAS Number:
145821-59-6
Molecular Weight:
375.55 (free base basis)
MDL number:
MFCD07369025
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

Quality Level

100

form

solid

potency

67 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

water: soluble

storage temp.

2-8°C

InChI

1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1

InChI key

YUKARLAABCGMCN-PKLMIRHRSA-N

General description

A potent uptake inhibitor highly selective for GABA Transport-1 (IC50 = 67 nM in vivo). Clinically used as an anticonvulsant. Often used in studies related to anxiety disorders and neural damages resulted from epileptics.

Biochem/physiol Actions

Primary Target
GAT-1

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Laughlin, T., et al. 2002. J. Pharmacol. Exp. Ther.302, 1168.

Hu, Q., et al. 1997. Brain Res.753,260.
Suzdak, P., et al., 1995. Epilepsia.36, 612.
Andersen, E., et al., 1993. J. Med. Chem.36, 1716.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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