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Merck
CN

5.06188

Sertraline Hydrochloride

Synonym(s):

Sertraline Hydrochloride, Serotonin (5-HT) Reuptake Inhibitor, Sertraline, Zoloft

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About This Item

Empirical Formula (Hill Notation):
C17H17Cl2N · xHCl
CAS Number:
Molecular Weight:
306.23 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
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SMILES string

[Cl-].Clc1c(ccc(c1)[C@@H]2CC[C@@H](c3c2cccc3)[N+H2]C)Cl

InChI

1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1

InChI key

BLFQGGGGFNSJKA-XHXSRVRCSA-N

assay

≥99% (HPLC)

form

solid

potency

3.3 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mM
ethanol: 50 mM

storage temp.

2-8°C

Quality Level

Disclaimer

Toxicity: Standard Handling (A)

Biochem/physiol Actions

Primary Target
5-HT uptake transporter

General description

A very potent uptake inhibitor highly selective for serotonin (Ki = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.

Other Notes

Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383.

Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481.
Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40.
Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
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