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5.05986

Sigma-Aldrich

SR 95531

≥98% (HPLC), solid, GABAA receptor antagonist, Calbiochem®

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Synonym(s):
SR95531 (Gabazine), GABA A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531, GABAA Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531
Empirical Formula (Hill Notation):
C15H17N3O3 · xHBr
CAS Number:
104104-50-9
Molecular Weight:
287.31 (free base basis)
MDL number:
MFCD00055135
UNSPSC Code:
12352200
NACRES:
NA.77

product name

SR95531 (Gabazine),

Assay

≥98% (HPLC)

Quality Level

100

form

solid

potency

440 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 25 mM

storage temp.

2-8°C

InChI

1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H

InChI key

GFZHNFOGCMEYTA-UHFFFAOYSA-N

General description

A selective, competitive antagonist of GABAA receptor (IC50 = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 µM). Also shown to block glycine receptors, but with low affinity (Kb = 190 µM).
A selective, competitive antagonist of GABAA receptor (IC50 = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 mM). Also shown to block glycine receptors, but with low affinity (Kb = 190 mM).

Biochem/physiol Actions

Primary Target
GABAA

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Muroi, Y., et al. 2009. Biophys. J.96, 499.
Beato, M., et al. 2007. J. Physiol.580, 171.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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