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5.05895

Sigma-Aldrich

CGP 35348

Synonym(s):

CGP 35348, GABA B Receptor Antagonist, CGP 35348, CGP35348, CGP-35348

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About This Item

Empirical Formula (Hill Notation):
C8H20NO4P
CAS Number:
123690-79-9
Molecular Weight:
225.22
UNSPSC Code:
12352200

Assay

≥98% (TLC)

Quality Level

100

form

solid

potency

34 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 100 mM

storage temp.

−20°C

InChI

1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)

InChI key

QIIVUOWTHWIXFO-UHFFFAOYSA-N

General description

A selective antagonist of post-synaptic GABAB receptors (IC50 = 34 µM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices.
A selective antagonist of post-synaptic GABAB receptors (IC50 = 34 mM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices.

Biochem/physiol Actions

Primary Target
GABAB

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Romei, C., et al., 2010. Pharmacol. Res.61, 547.

Staubli, U., et al., 1999. J. Neurosci.19, 4609l.
Olpe, H.R., et al. 1990. Eur. J. Pharmacol.187, 27.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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