All Photos(1)
Synonym(s):
L-745,870 Trihydrochloride, Dopamine D₄ receptor Antagonist, L-745,870 trihydrochloride, L-745870, L745870
Empirical Formula (Hill Notation):
C18H19ClN4 · 3HCl
Recommended Products
Assay
≥99% (HPLC)
Quality Level
form
solid
potency
0.4 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
water: soluble
storage temp.
2-8°C
InChI
1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
InChI key
OGJGQVFWEPNYSB-UHFFFAOYSA-N
General description
Selective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4 nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation.
Biochem/physiol Actions
Primary Target
D₄
D₄
Reversible: yes
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Li, H. et al., 2013. J. Neurosci.33, 3135.
Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Kulagowski, J. et al. 1996. J. Med. Chem.39, 1941.
Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Kulagowski, J. et al. 1996. J. Med. Chem.39, 1941.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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