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5.05877

Sigma-Aldrich

(S)-(-)-Raclopride

Synonym(s):

(S)-(-)-Raclopride, Dopamine Receptor D2 Antagonist, (S)-Raclopride, Raclopride

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About This Item

Empirical Formula (Hill Notation):
C15H20Cl2N2O3
CAS Number:
84225-95-6
Molecular Weight:
347.24
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 100 mM
ethanol: 25 mM

storage temp.

2-8°C

InChI

1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m1/s1

InChI key

WAOQONBSWFLFPE-SECBINFHSA-N

General description

D2-like dopamine receptor antagonist targeting D2R (pKi =8.0), D3R (pKi = 7.9), and 5-HT1A R (pKi=5.2). Used to explore D2 like receptor mediated effects in neuropathic pain, and in antagonism studies of DA receptors during heroin usage and cocaine. D2 Receptor selectivity in various preps shows IC50 values around 32 nM.

Biochem/physiol Actions

Reversible: yes

Warning

Toxicity: Standard Handling (A)

Other Notes

Dang, Y. H. et al. 2010. Neurosci.169, 1872.

Platt, D. M. et al. 2010. J. Pharmacol. Exp. Ther.332, 985.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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