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5.05762

Sigma-Aldrich

(+/-)-Clopidogrel Hydrogensulfate

Synonym(s):

(+/-)-Clopidogrel Hydrogensulfate, Purinergic P2Y12 Receptor Antagonist, (+/-)-Clopidogrel, Plavix

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About This Item

Empirical Formula (Hill Notation):
C16H16ClNO2S · xH2SO4
CAS Number:
135046-48-9
Molecular Weight:
321.82 (free base basis)
MDL number:
MFCD05865229
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 25 mg/mL

storage temp.

2-8°C

InChI

1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)

InChI key

FDEODCTUSIWGLK-UHFFFAOYSA-N

General description

A thienopyridine compound that acts as a specific irreversible inhibitor of purinergic P2Y12 receptors. Blocks ADP-induced platelet aggregation and serves as an anti-thrombotic agent. Shown to reduce vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. Clopidogrel is a prodrug that requires activation by CYP enzyme system to produce its pharmacologically active metabolite.

Biochem/physiol Actions

Primary Target
P2Y₁₂
Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Liu, O., et al. 2012. PLoS One.7, e51707.

Savi, P., et al. 2005. Semin. Thromb. Hemost.31, 174.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionEnvironment
GHS05,GHS09

Signal Word

Danger

Hazard Statements

H314 - H411

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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