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5.05736

Sigma-Aldrich

5-BDBD

Synonym(s):

5-BDBD, 5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD

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About This Item

Empirical Formula (Hill Notation):
C17H11BrN2O2
CAS Number:
768404-03-1
Molecular Weight:
355.19
MDL number:
MFCD18086878
UNSPSC Code:
12352200

Assay

≥99% (HPLC)

Quality Level

100

form

powder

potency

500 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 15 mg/mL

storage temp.

2-8°C

InChI

1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)

InChI key

NKYMVQPXXTZHSF-UHFFFAOYSA-N

General description

A highly potent antagonist of purinergic P2X4 receptor. Shown to block P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 500 nM). Blocks ATP-induced dilation of spiral ligament capillaries in guinea pigs. Also shown to restore the viability of activated CD4+ cells in the presence of 1 mM ATP.

Biochem/physiol Actions

Primary Target
P2X₄

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Trabanelli, S., et al. 2012. J. Immunol.189, 1303.
Wu, T., et al. 2011. Am. J. Physiol.301, H69.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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