Skip to Content
Merck
CN

5.04905

Memantine Hydrochloride

Synonym(s):

Memantine Hydrochloride, 3,5-Dimethyl-1-adamantanamine hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C12H21N · xHCl
CAS Number:
41100-52-1
Molecular Weight:
179.30 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00214336

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

SMILES string

[Cl-].[N+H3]C21CC3(CC(C2)(CC(C1)C3)C)C

InChI

1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H

InChI key

LDDHMLJTFXJGPI-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

H2O: 100 mM

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Primary Target
NMDA receptors
Target IC50: 0.8, 0.57, 0.52, and 0.54 →M for GluN2A, B, C, and D, respectively.

Disclaimer

Toxicity: Standard Handling (A)

General description

A very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.

Other Notes

Limapichat, W., et al. 2012. ACS Chem. Neurosci.4, 255.
Anand, A., et al. 2012. Bipolar Dis.14, 64.
Lopes, P., et al. 2013. Brain and Behavior.3, 67.
Howard, R., et al. 2012. New Eng. J. Med.366, 893.
Parsons, G., et al. 1999. Neuropharmacol.38, 735.
Lee, G., et al. 2012. Psychiatry Investig.9, 166.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service