All Photos(1)
Synonym(s):
5,7-Dichlorokynurenic Acid, Sodium Salt, 5,7-Dichloro-4-hydroxyquinoline-2-c-arboxylic acid sodium salt, DCKA
Empirical Formula (Hill Notation):
C10H4Cl2NNaO3
Recommended Products
Assay
≥99% (HPLC)
Quality Level
form
solid
potency
79 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
water: 10 mM
1 M NaOH: 100 mM
storage temp.
2-8°C
InChI
1S/C10H5Cl2NO3.Na/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14;/h1-3H,(H,13,14)(H,15,16);/q;+1/p-1
InChI key
VPRPMJHKWHCUFW-UHFFFAOYSA-M
General description
A very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (Ki = 79 nM vs. [3H]-glycine).
Biochem/physiol Actions
Primary Target
NMDA receptors
NMDA receptors
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Baron, B., et al. 1991. Eur. J. Pharmacol.206, 149.
Baron, B., et al. 1990. Mol. Pharmacol.38, 554.
Mugnaini, M., et al. 1998. J. Recept. Signal Transduct. Res.18, 91.
Baron, B., et al. 1990. Mol. Pharmacol.38, 554.
Mugnaini, M., et al. 1998. J. Recept. Signal Transduct. Res.18, 91.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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