All Photos(1)
Synonym(s):
MPEP Hydrochloride, 6-Methyl-2-(phenylethynyl)pyridine hydrochloride
CAS Number:
UNSPSC Code:
12352200
Recommended Products
Assay
≥99% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 100 mM
storage temp.
2-8°C
InChI
1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
InChI key
NEWKHUASLBMWRE-UHFFFAOYSA-N
General description
A non-competitive, highly potent antagonist selective for mGlu5 receptors (IC50 = 36 nM). Also a positive allosteric modulator of mGlu4and weak anatagonist of NMDA receptors. Biologically active admitted systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as learning and memory, sleep, neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson′s disease.
Biochem/physiol Actions
Primary Target
mGlu₅ receptors
mGlu₅ receptors
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Manago, F., et al. 2013. Psychopharmacol. (Berl)226, 541.
Cavas, M., et al. 2013. Prog. Neuropsychopharmacol. Biol. Psychiatry.40, 18.
Micheli, F., 2000. Cur. Op. Invest. Drugs (London, England)1, 355.
Li, X., et al. 2006. J. Pharmacol. & Exp. Therapeutics.319, 254.
Tatarczyñska, E., et al. 2001. Bri. J. Pharmacol.132, 1423.
Cavas, M., et al. 2013. Prog. Neuropsychopharmacol. Biol. Psychiatry.40, 18.
Micheli, F., 2000. Cur. Op. Invest. Drugs (London, England)1, 355.
Li, X., et al. 2006. J. Pharmacol. & Exp. Therapeutics.319, 254.
Tatarczyñska, E., et al. 2001. Bri. J. Pharmacol.132, 1423.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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