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Safety Information

5.04523

Sigma-Aldrich

CP-101,606

Synonym(s):

CP-101,606, Traxoprodil, CP-101606, (1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol, NMDA Antagonist VI

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About This Item

Empirical Formula (Hill Notation):
C20H25NO3
CAS Number:
134234-12-1
Molecular Weight:
327.42
MDL number:
MFCD00926469
UNSPSC Code:
12352200

Assay

≥98% (HPLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 35 mg/mL

storage temp.

2-8°C

InChI

1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1

InChI key

QEMSVZNTSXPFJA-HNAYVOBHSA-N

General description

A highly selective antagonist for NR2B subunit containing NMDA receptors (IC50 = 0.039 µM for NR2B and >100 µM for NR2A, NR2C, and NR2D). Widely used as neuroprotective, analgesic, antidepressant, and anti-Parkinsonian agent in research.

Biochem/physiol Actions

Primary Target
NMDA receptors
Target IC50: 0.039 µM for NR2B and >100 µM for NR2A, NR2C, and NR2D

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Taniguchi, K., et al. 2009. British J. Pharmacol.122, 809.
Menniti, F., et al. 1997. Eur. J. Pharmacol.331, 117.

Nicholson, K., et al. 2007. Behavioural Pharmacology18, 731.
Bullock, M., et al. 2006. Annals of the New York Academy of Sciences890, 51.

Preskorn, S., et al. 2008. J. Clin. Psychopharmacol.28, 631.

Yurkewicz, L., et al. 2005. J. Neurotrauma.22, 1428.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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