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5.04359

Sigma-Aldrich

Palmitoylethanolamide

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Synonym(s):
Palmitoylethanolamide, N-(2-Hydroxyethyl)hexadecanamide, PEA, Palmidrol
Empirical Formula (Hill Notation):
C18H37NO2
CAS Number:
544-31-0
Molecular Weight:
299.49
MDL number:
MFCD00020562
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥99% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 20 mM

storage temp.

−20°C

InChI

1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)

InChI key

HXYVTAGFYLMHSO-UHFFFAOYSA-N

General description

An endogenous lipid that acts as a selective agonist for GPR55 receptors (EC50 = 4, 19 800 and >30 000 nM at GPR55, CB2 and CB1 receptors respectively). Producing robust anti-inflammatory actions by activating PPARα (EC50 = 3 µM).

Biochem/physiol Actions

Primary Target
GPR55 receptor

Warning

Toxicity: Standard Handling (A)

Preparation Note

Slight warming is required for complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Griffin, G., et al. 2000. J. Pharmacol. Exp. Ther.292, 886.

Lambert, D., et al. 2001. Epilepsia.42, 321.
Lambert, D., et al. 2002. Curr. Med. Chem.9, 663.
Lo Verme, J., et al. 2005. Life Sci.77, 1685.
Re, G., et al. 2005. Vet. J.173, 21.
Ryberg, R., et al. 2007. Br. J. Pharmacol.152, 1092.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionEnvironment
GHS05,GHS09

Signal Word

Danger

Hazard Statements

H315 - H318 - H411

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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