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Merck
CN

5.04275

CB1 antagonist AM251

Synonym(s):

CB1 antagonist AM251, N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide, AM 251

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About This Item

Empirical Formula (Hill Notation):
C22H21Cl2IN4O
CAS Number:
183232-66-8
Molecular Weight:
555.24
UNSPSC Code:
12352200
MDL number:
MFCD01861181

Key Documents

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form

solid

InChI

1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)

InChI key

BUZAJRPLUGXRAB-UHFFFAOYSA-N

assay

≥98% (HPLC)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 10 mg/mL

storage temp.

10-30°C

Quality Level

100

Biochem/physiol Actions

Primary Target
CB₁ Receptor

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent and highly selective antagonist for cannabinoid subtyre 1 (CB1) receptor. Affinity for CB1 (IC50 = 8 nM, Ki = 7.49 nM) is more than 306-fold higher than that for CB2 receptors. Has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice.

Other Notes

Gatley, S., et al. 1996. Eur. J. Pharmacol.307, 331.
Gatley, S., et al. 1997. Life Sci.61, 191.
Lan, R., et al. 1999. J. Med. Chem.42, 769.
Pertwee, R., 2005. Life Sci.76, 1307.

Ryberg, E., et al. 2007. Br. J. Pharmacol.152, 1092.
Assini, F., et al. 2012. Behav. Pharmacol.23, 292.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_c

Not applicable

Regulatory Information

新产品
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