All Photos(1)
CB1 antagonist AM251, N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide, AM 251
C22H21Cl2IN4O
Recommended Products
Assay
≥98% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 10 mg/mL
storage temp.
10-30°C
InChI
1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
InChI key
BUZAJRPLUGXRAB-UHFFFAOYSA-N
General description
A potent and highly selective antagonist for cannabinoid subtyre 1 (CB1) receptor. Affinity for CB1 (IC50 = 8 nM, Ki = 7.49 nM) is more than 306-fold higher than that for CB2 receptors. Has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice.
Biochem/physiol Actions
Primary Target
CB₁ Receptor
CB₁ Receptor
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Gatley, S., et al. 1996. Eur. J. Pharmacol.307, 331.
Gatley, S., et al. 1997. Life Sci.61, 191.
Lan, R., et al. 1999. J. Med. Chem.42, 769.
Pertwee, R., 2005. Life Sci.76, 1307.
Ryberg, E., et al. 2007. Br. J. Pharmacol.152, 1092.
Assini, F., et al. 2012. Behav. Pharmacol.23, 292.
Gatley, S., et al. 1997. Life Sci.61, 191.
Lan, R., et al. 1999. J. Med. Chem.42, 769.
Pertwee, R., 2005. Life Sci.76, 1307.
Ryberg, E., et al. 2007. Br. J. Pharmacol.152, 1092.
Assini, F., et al. 2012. Behav. Pharmacol.23, 292.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service