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Key Documents

487955

Sigma-Aldrich

NOC-12

A nitric oxide (NO) donor similar to NOC-5 and NOC-7 but with a much longer half-life of NO release.

Synonym(s):

NOC-12, N-Ethyl-2-(1-ethyl-2-hydroxy-2-nitrosohydrazino)ethanamine

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About This Item

Empirical Formula (Hill Notation):
C6H16N4O2
CAS Number:
146724-89-2
Molecular Weight:
176.22
MDL number:
MFCD00674898
UNSPSC Code:
12352200

Quality Level

100

Assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

0.1 M NaOH: soluble
water: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C6H16N4O2/c1-3-7-5-6-9(4-2)10(12)8-11/h7,11H,3-6H2,1-2H3/b10-8-

InChI key

DPKCLDSTXVCYSN-NTMALXAHSA-N

General description

A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950) and NOC-7 (Cat. No. 487952) but with a much longer half-life of NO release. Half-life (t½) in PBS, pH 7.4 is 327 minutes at 22°C. Inhibits the proliferation of arterial smooth muscle cells in a dose-dependent manner. Relatively stable in alkaline solution (pH ≥10.0).
A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950) and NOC-7 (Cat. No. 487952) but with a much longer half-life of NO release. Half-life (t½) of NO release is 327 min (PBS, pH 7.4, 22°C). Inhibits the proliferation of arterial smooth muscle cells in a dose-dependent manner. Relatively stable in alkaline solution (pH ≥10.0).

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Irritant (B)

Other Notes

Ambalavanan, N., et al. 1999. Biol. Neonate76, 291.
Hrabie, J.A., et al. 1993. J. Org. Chem.58, 1472.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Flame
GHS02

Signal Word

Danger

Hazard Statements

H242

Hazard Classifications

Self-react. C

Storage Class Code

5.2 - Organic peroxides and self-reacting hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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