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Merck
CN

48-610MAG

MILLIPLEX® STAT Signaling Panel

Premixed STAT Phosphoprotein 5-Plex Cell Signaling Panel

Synonym(s):

Magnetic Bead STAT Kit, STAT Cell Signaling Kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000

Key Documents

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Product Name

MILLIPLEX® STAT Signaling Panel, Premixed STAT Phosphoprotein 5-Plex Cell Signaling Panel

Quality Level

200

species reactivity

human

manufacturer/tradename

Milliplex®

packaging

1 ea of

technique(s)

multiplexing: suitable

input

cell lysate

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

Application

Research Category
Signaling|Apoptosis & Cancer
The analytes available for this multiplex kit are: STAT1 (Tyr701), STAT2 (Tyr690), STAT3 (Tyr705), STAT5A/B (Tyr694/699), STAT6 (Tyr641).
Used to detect/quantify:STAT1 (Tyr701)|STAT2 (Tyr690)|STAT3 (Tyr705)|STAT5A/B (Tyr694/699)|STAT6 (Tyr641)
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 5 analytes in cell lysate samples.Analytes Included: STAT1 (pY701), STAT3 (pS727), STAT3 (pY705), STAT5A/B (pY694/699), STAT6 (pY641)Assay Characteristics: Refer to the assay protocol for details on cross-reactivity, buffer compatibility, lysate control, and recommended loading control (MAPmate™ Control Assays).

Biochem/physiol Actions

Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

General description

The STAT (Signal Transducers and Activators of Transcription) family, consisting of seven mammalian members, regulates many aspects of growth, survival and differentiation in cells. The extracellular binding of cytokines, hormones, growth factors and neurotransmitters to receptors induces phosphorylation of the intracellular Janus kinases (JAKs) that, in turn, phosphorylate STAT proteins at conserved tyrosine residues, activating SH2-mediated dimerization followed by translocation to the nucleus. STAT dimers then bind to IRE (interferon response element) and GAS (gamma interferon-activated sequence) DNA elements, resulting in the transcriptional regulation of downstream genes.
This panel targets phosphorylated STAT proteins, which are critical mediators of cytokine and growth factor signaling. STAT1 (pY701) and STAT3 (pY705, pS727) are involved in immune response, inflammation, and cell survival. STAT5A/B (pY694/699) plays a role in hematopoiesis and immune cell development. STAT6 (pY641) is primarily activated by IL-4 and IL-13, contributing to Th2 cell differentiation and allergic responses.

Packaging

96-well plate

Preparation Note

Recommended storage for kit components is 2 - 8°C.

Legal Information

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
Luminex is a registered trademark of Luminex Corp
xMAP is a registered trademark of Luminex Corp
MAPMATE is a trademark of Merck KGaA, Darmstadt, Germany

Features and Benefits

  • Simultaneously detect 5 phosphorylated STAT proteins involved in cytokine and growth factor signaling
  • Includes STAT1, STAT3, STAT5A/B, and STAT6 for focused pathway analysis
  • Magnetic bead-based format ensures reproducibility and efficient processing
  • Compatible with cell lysates from immune and cancer-related studies
  • Ideal for inflammation, immune regulation, and oncology research
  • Fast, convenient alternative to Western Blotting and immunoprecipitation procedures

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - ED ENV 1 - Eye Dam. 1 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

wgk

WGK 3

Regulatory Information

新产品
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