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481408-M

NF-κB Activation Inhibitor II, JSH-23

Name: NF-κB Activation Inhibitor II, JSH-23
Brand: MM

The NF-κB Activation Inhibitor II, JSH-23, also referenced under CAS 749886-87-1, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Synonym(s):

NF-κB Activation Inhibitor II, JSH-23, 4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₀N₂

CAS Number:

749886-87-1

Molecular Weight:

240.34

UNSPSC Code:

12352200

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 10 mg/mL

storage temp.

−20°C

InChI

1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3

InChI key

YMFNPBSZFWXMAD-UHFFFAOYSA-N

General description

A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC₅₀ = 7.1 µM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.

A cell-permeable, selective blocker of the nuclear translocation of NF-κB p65 that does not affect IκB degradation (IC₅₀ = 7.1 µM in LPS-stimulated macrophages RAW 264.7 stably transfected with pNF-κB-SEAP-NPT). Shown to suppress DNA-binding of NF-κB and downregulate LPS-inducible expression of TNF-α, IL-1β, IL-6, iNOS, and COX-2. Also prevents LPS-induced apoptotic chromatin condensation.

Biochem/physiol Actions

Primary Target
Blocks nuclear translocation of NF-κB p65 and its transcription activity

Target IC₅₀: 7.1 µM in a NF-κB reporter assay using RAW 264.7

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Shin, H.M., et al. 2004. FEBS Lett.571, 50.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

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