480404
NFAT Inhibitor, MCV1
The NFAT Inhibitor, MCV1 controls the biological activity of NFAT.
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Synonym(s):
NFAT Inhibitor, MCV1, Maleimido-conjugated VIVIT 1, MPB-HPVIVIT, Maleimido-conjugated HPVIVIT
Empirical Formula (Hill Notation):
C51H75N10O12
Molecular Weight:
1020.20
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable, synthetic maleimido-conjugated VIVIT motif peptide (HPVIVIT) that acts as a potent bipartite inhibitor of Nuclear factor of activated T-cells (NFAT) (IC50 = 62 nM). Blocks NFAT-calcineurin interaction by targeting two separate calcineurin docking motifs. Completely blocks NFAT dephosphorylation at 1 mM. Determined to be more potent that Cyclosporine A (Cat. No. 239835) and VIVIT peptide (MAGPHPVIVITGPHEE) in blocking NFAT activity. Also shown to blocks NFAT-mediated T-cell activation and vascular smooth muscle cell proliferation, thereby reducing neoimtima (new thickening of arterial wall) formation in mouse models of restenosis (repeat blocking of blood vessels). The biological half life of MCV1 has been estimated to be about 36 hours in COS-1 cells.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Yu, H., et al. 2012. Circulation Res.110, 200.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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