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476480

Sigma-Aldrich

PKC 20-28, Cell-Permeable, Myristoylated

Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ).

Synonym(s):

PKC 20-28, Cell-Permeable, Myristoylated, Myr-N-FARKGALRQ-NH₂, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Protein Kinase C 20-28, Cell-Permeable, Myristoylated, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Myr-N-FARKGALRQ-NH₂, Protein Kinase C 20-28, Cell-Permeable, Myristoylated

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About This Item

Empirical Formula (Hill Notation):
C60H106N18O11
Molecular Weight:
1255.60
UNSPSC Code:
12352200

Quality Level

100

Assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

water: 10 mg/mL
Tris-HCl, pH 7.5: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ). N-Terminus is myristoylated to allow membrane permeability. Highly specific, reversible, and substrate competitive inhibitor of TPA activation of MARCKS phosphorylation in fibroblast primary cultures (IC50 = 8 µM); exhibits 98% inhibition at 100 µM.
Pseudosubstrate sequence from protein kinase Ca (PKCα) and PKCβ. N-terminal myristoylated to allow membrane permeability. Highly specific, reversible, and substrate competitive inhibitor of TPA activation of MARCKS phosphorylation in fibroblast primary cultures (IC50 = 8 µM). Exhibits 98% inhibition at 100 µM.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
TPA activation of MARCKS phosphorylation in fibroblast primary cultures
Product does not compete with ATP.
Reversible: yes
Target IC50: 8 µM against TPA activation of MARCKS phosphorylation in fibroblast primary cultures

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

N-Myr-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-NH₂

Other Notes

Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982.
Ward, N.E. and O’Brian, C.A. 1993. Biochemistry32, 11903.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Carsten Riether et al.
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Self-renewal is a key characteristic of leukemia stem cells (LSCs) responsible for the development and maintenance of leukemia. In this study, we identify CD93 as an important regulator of self-renewal and proliferation of murine and human LSCs, but not hematopoietic

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