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Sigma-Aldrich

Mycophenolic Acid

An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP.

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Synonym(s):
Mycophenolic Acid, 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid, MPA
Empirical Formula (Hill Notation):
C17H20O6
CAS Number:
24280-93-1
Molecular Weight:
320.34
MDL number:
MFCD00036814
UNSPSC Code:
12352106
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

0.1 M NaOH: 10 mg/mL
ethanol: soluble

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+

InChI key

HPNSFSBZBAHARI-RUDMXATFSA-N

General description

An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.
An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of IMP dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Inosine monophosphate dehydrogenase
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Following reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Langman, L.J., et al. 1995. Clin. Chem. 41, 295.
Senda, M., et al. 1995. Transplantation60, 1143.
Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res.204, 241.
Falkner, F.G., and Moss, B. 1988. J. Virol.62, 1849.
Cohen, M.B., et al. 1981. J. Biol. Chem.256, 8713.
Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA78, 2072.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

H302,H341,H360D,H372,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Repr. 1B - STOT RE 1 Oral

Target Organs

Immune system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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