475847
MIF Antagonist IV, RDR 03785
The MIF Antagonist IV, RDR 03785 controls the biological activity of MIF. This small molecule/inhibitor is primarily used for Cell Structure applications.
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Synonym(s):
MIF Antagonist IV, RDR 03785, Macrophage Migration Inhibitory Factor Antagonist IV, 6-(Morpholino(4-(trifluoromethyl)phenyl)methyl)-1,3-benzodioxol-5-ol
Empirical Formula (Hill Notation):
C19H18F3NO4
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
cream
solubility
DMSO: 50 mg/mL, clear, colorless
shipped in
ambient
storage temp.
2-8°C
SMILES string
C1COCCN1C(C2=CC=C(C=C2)C(F)(F)F)C3=CC4=C(C=C3O)OCO4
General description
A cell-permeable morpholino-benzodioxol compound that inhibits MIF tautomerase activity (Ki and IC50 = 0.57 and 2.4 µM, respectively) via direct non-covalent MIF interaction (KD = 24.5 µM). RDR 03758 at 10 µM is shown to completely neutralize the overriding effect of 100 ng/ml MIF on the inhibition of LPS-stimulated TNF production by dexamethasone (Cat. No. 265005) in RAW 264.7 marcophage cultures.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Ouertatani-Sakouhi, H., et al. 2010. J. Biol. Chem.285, 26581.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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