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445888

Sigma-Aldrich

Metastin (45-54)

A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors).

Synonym(s):

Metastin (45-54), KiSS-1 (112-121), Kisspeptin-10, H-YNWNSFGLRF-NH₂

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About This Item

Empirical Formula (Hill Notation):
C63H83N17O14
Molecular Weight:
1302.44
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥97% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptor). More potent than the parent peptide. Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM, determined by competitive binding analysis) as compared to Metastin (Cat. No. 444885).
A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM) compared to Metastin (Cat. No. 445885).

Biochem/physiol Actions

Cell permeable: no
Primary Target
AXOR12 and hOT7T175
Product does not compete with ATP.
Reversible: no
Target Ki: 42 pM for AXOR12 and hOT7T175

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

Other Notes

Kotani, M., et al. 2001. J. Biol. Chem.276, 34631.
Ohtaki, T., et al. 2001. Nature411, 613.
Muir, A.I., et al. 2001. J. Biol. Chem.276, 28969.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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