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Merck
CN

444965

MEK Inhibitor VIII

The MEK1/2 Inhibitor II, also referenced under CAS 212631-61-3, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

MEK Inhibitor VIII, N-Cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methylphenylamino)benzamide

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About This Item

Empirical Formula (Hill Notation):
C18H16F3IN2O2
CAS Number:
212631-61-3
Molecular Weight:
476.23
UNSPSC Code:
12352200

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Product Name

MEK Inhibitor VIII, The MEK1/2 Inhibitor II, also referenced under CAS 212631-61-3, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InChI key

UHAXDAKQGVISBZ-UHFFFAOYSA-N

InChI

1S/C18H16F3IN2O2/c1-9-6-11(22)4-5-14(9)23-17-12(7-13(19)15(20)16(17)21)18(25)24-26-8-10-2-3-10/h4-7,10,23H,2-3,8H2,1H3,(H,24,25)

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 45 mg/mL
ethanol: 45 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable and orally available amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC50 = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk′s, and PI 3-Kγ (IC50 >1.0 µM). Reported to exhibit in vivo efficacy in several animal models of arthritis and hyperalgesia in rat and rabbit.

Other Notes

Pelletier, J.P., et al. 2003. Arthritis Rheum.48, 1582.
Ciruela, A., et al. 2003. Br. J. Pharmacol.138, 751.
Bhattachar, S.N., et al. 2002. Int. J. Pharm.236, 135.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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