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444896

Sigma-Aldrich

MAS 7

A cell-permeable, amphiphilic, mastoparan analog with five-fold greater potency than Mastoparan.

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Synonym(s):
MAS 7
Empirical Formula (Hill Notation):
C67H124N18O15
CAS Number:
145854-59-7
Molecular Weight:
1421.81
MDL number:
MFCD00144726
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C67H124N18O15/c1-18-38(12)53(71)67(100)85-51(32-52(70)86)66(99)84-50(31-37(10)11)64(97)79-45(24-20-22-26-69)61(94)75-42(16)58(91)82-47(28-34(4)5)62(95)76-39(13)55(88)73-40(14)57(90)81-48(29-35(6)7)63(96)77-41(15)56(89)78-44(23-19-21-25-68)60(93)74-43(17)59(92)83-49(30-36(8)9)65(98)80-46(54(72)87)27-33(2)3/h33-51,53H,18-32,68-69,71H2,1-17H3,(H2,70,86)(H2,72,87)(H,73,88)(H,74,93)(H,75,94)(H,76,95)(H,77,96)(H,78,89)(H,79,97)(H,80,98)(H,81,90)(H,82,91)(H,83,92)(H,84,99)(H,85,100)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,53-/m0/s1

InChI key

HOLQXBRPSSZJMZ-FGRXCANLSA-N

General description

A cell-permeable, amphiphilic, mastoparan analog with five-fold greater potency than Mastoparan Cat. No. 444898. An activator of α-subunit of G-proteins. Evokes rapid upregulation of FAK tyrosine phosphorylation via activation of G-proteins.
Mastoparan analog with five-fold greater potency than mastoparan. An activator of the α-subunit of G -proteins. Evokes a rapid upregulation of FAK tyrosine phosphorylation via activation of G-proteins.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
α-subunit of G-proteins
Product does not compete with ATP.
Reversible: no

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Ala-Leu-Leu-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Mironov, S.L., and Richter, D.W. 2000. Brain Res.853, 60.
Park, H.S., et al. 2000. Biochim. Biophys. Acta1484, 151.
Zhang, C., et al. 1996. FEBS Lett. 386, 185.
Leyte, A., et al. 1992. EMBO J.11 4795.
Higashijima, T., et al. 1990. J. Biol. Chem.265, 14176.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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