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444605

Sigma-Aldrich

Melittin

A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner.

Synonym(s):

Melittin

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About This Item

Empirical Formula (Hill Notation):
C131H229N39O31
CAS Number:
37231-28-0
Molecular Weight:
2846.46
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

>97% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)

InChI key

VDXZNPDIRNWWCW-UHFFFAOYSA-N

General description

A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner, activates phospholipase A2, and inhibits protein kinase C (IC50 = 5-7 µM) by binding to the catalytic domain in a Mg2+-ATP sensitive manner. A stimulator of Giα and G11α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Has also been used for affinity purification of several Ca2+-binding proteins. Activates Giα-1 and G11α activities and inhibits Gs activity.
A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner. A stimulator of Giα and G11α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Activates phospholipase A2 and inhibits protein kinase C (IC50 = 5-7 µM) by binding to the catalytic domain in a Mg2+-ATP sensitive manner. Has also been used for affinity purification of several Ca2+-binding proteins.

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 5-7 µM 5-7 µM for activating phospholipase A2 and inhibits protein kinase C

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂

Other Notes

Fukushima, N., et al. 1998. Peptides19, 811.
Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
Baudier, J., et al. 1987. Biochemistry26, 2886.
Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun.133, 256.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Certificates of Analysis (COA)

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