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444200

Sigma-Aldrich

MDL-12,330A, Hydrochloride

Cell-permeable and irreversible inhibitor of adenylate cyclase (IC₅₀ = 250 µM).

Synonym(s):

MDL-12,330A, Hydrochloride, cis-N-(2-Phenylcyclopentyl)azacyclotridec-1-en-2-amine, HCl, RMI 12330

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About This Item

Empirical Formula (Hill Notation):
C23H36N2 · xHCl
CAS Number:
40297-09-4
Molecular Weight:
340.55 (free base basis)
MDL number:
MFCD00210204
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 10 mg/mL
water: 3 mg/mL
ethanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C23H36N2.ClH/c1-2-4-6-11-18-23(24-19-12-7-5-3-1)25-22-17-13-16-21(22)20-14-9-8-10-15-20;/h8-10,14-15,21-22H,1-7,11-13,16-19H2,(H,24,25);1H/t21-,22-;/m0./s1

InChI key

CKOPQUCSDBVAQG-VROPFNGYSA-N

General description

Cell-permeable and irreversible inhibitor of adenylate cyclase (IC50 = 250 µM).
Cell-permeable irreversible inhibitor of adenylate cyclase (IC50 = 250 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Adenylate cyclase
Product does not compete with ATP.
Reversible: no
Target IC50: 250 µM against adenylate cyclase

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Correia-de-Sa, P., and Ribeiro, J.A. 1994. Eur. J. Pharmacol. 271, 349.
Gorczynska, E., et al. 1994. Endocrinology134, 293.
Delpiano, M.A., and Acker, H. 1991. J. Neurochem.57, 291.
Lippe, C., and Ardizzone, C. 1991. Comp. Biochem. Physiol.99, 209.
Guellaen, G., et al. 1977. Biochim. Biophys. Acta 484, 465.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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