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444170-M

Millipore

Manumycin A, Streptomyces parvulus

An antibiotic with antitumor properties.

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Synonym(s):
Manumycin A, Streptomyces parvulus
Empirical Formula (Hill Notation):
C31H38N2O7
CAS Number:
52665-74-4
Molecular Weight:
550.64
MDL number:
MFCD00920782
UNSPSC Code:
12352200

Assay

≥96% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow to brown

solubility

DMSO: 10 mg/mL
chloroform: soluble
methanol: soluble

storage temp.

2-8°C

InChI

1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-,29-,31+/m1/s1

InChI key

TWWQHCKLTXDWBD-MVTGTTCWSA-N

General description

An antibiotic with antitumor properties. A cell-permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 5 µM) compared to geranylgeranyltransferase I (GGTase I; IC50 = 180 µM). Manumycin acts as a competitive inhibitor of FTase with respect to farnesylpyrophosphate (FPP; Ki = 1.2 µM), but acts as a noncompetitive inhibitor with respect to the Ras acceptor protein. Reported to inhibit the growth and invasive activity of pancreatic cancer cells.
An antibiotic with antitumor properties. A potent and selective inhibitor of farnesyltransferase (FTase, IC50 = 5 µM) compared to geranyl-geranyltransferase I (GGTase, IC50 = 180 µM). Manumycin acts as a competitive inhibitor of FTase with respect to farnesylpyrophosphate (FPP, Ki = 1.2 µM), but as a noncompetitive inhibitor with respect to the Ras acceptor protein. Reported to inhibit the growth and invasive activity of pancreatic cancer cells.

Biochem/physiol Actions

Primary Target
Farnesyltransferase (FTAse)
Target IC50: 5 µM against farnesyltransferase (FTase); 180 µM against geranylgeranyltransferase I (GGTase I)

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Kainuma, O., et al. 1997. Pancreas15, 379.
Nagase, T., et al. 1996. Int. J. Cancer 65, 620.
Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA92, 3333.
Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA90, 2281.
Tamanoi, R. 1993. Trends Biochem. Sci.18, 349.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

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