444151
Nutlin-3
InSolution, ≥98%, Racemic, potent and selective MDM2 antagonist
Synonym(s):
InSolution Nutlin-3, Racemic, MDM2 Inhibitor IV
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About This Item
Empirical Formula (Hill Notation):
C30H30Cl2N4O4
Molecular Weight:
581.49
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Physical form
A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Thompson, T., et al. 2004. J. Biol. Chem.279, 53015.
Vassilev, L.T., et al. 2004. Science303, 844.
Vassilev, L.T., et al. 2004. Science303, 844.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Flash Point(F)
closed cup
Flash Point(C)
closed cup
Certificates of Analysis (COA)
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