441251
α2-Macroglobulin, Human Plasma
A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases.
Synonym(s):
α₂M, α₂MG
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.77
Quality Level
Assay
≥95% (SDS-PAGE)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
aqueous buffer: soluble
shipped in
ambient
storage temp.
−20°C
General description
A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α2M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.
Biochem/physiol Actions
Cell permeable: no
Primary Target
broad range protease
broad range protease
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Physical form
Lyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.
Other Notes
Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236.
Lysiak, J.J., et al. 1995. J. Biol. Chem.270, 21919.
Boisset, N., et al. 1992. J. Struct. Biol.108, 221.
Barrett, A.J. 1980. Methods Enzymol.80, 737.
Lysiak, J.J., et al. 1995. J. Biol. Chem.270, 21919.
Boisset, N., et al. 1992. J. Struct. Biol.108, 221.
Barrett, A.J. 1980. Methods Enzymol.80, 737.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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