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440203

Sigma-Aldrich

LY 303511

A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002.

Synonym(s):

LY 303511, 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V

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About This Item

Empirical Formula (Hill Notation):
C19H18N2O2
CAS Number:
154447-38-8
Molecular Weight:
306.36
UNSPSC Code:
12352200

Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

amber

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C19H18N2O2/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13,20H,9-12H2

InChI key

NGAGMBNBKCDCDJ-UHFFFAOYSA-N

General description

A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not inhibit PI 3-kinase even at a concentration of 100 µM. Shown to bind to the same site as I-BET (Cat. no. 401010) and reversibly inhibit BET bromodomain proteins BRD2, BRD3 & BRD4 (IC50 ~10 µM).
A cell-permeable, negative control for the phosphatidylinositol-3-kinase (PI-3 kinase) inhibitor, LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not affect PI-3 kinase activity even at concentrations ≥100 µM.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Negative control for the PI 3-kinase inhibitor LY 294002
Product does not compete with ATP.
Reversible: no
Target IC50: Does not inhibit PI 3-kinase even at a concentration of 100 µM

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Dittman, et al. 2014. ACS Chem Biol.9, 495.
Ding, J., et al. 1995. J. Biol. Chem.270, 11684.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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