All Photos(1)

Documents

440025

Luteolin

Name: Luteolin
Brand: MM

An antioxidant flavonoid and a free radical scavenger.

Synonym(s):

Luteolin, 3ʹ,4ʹ,5,7-Tetrahydroxyflavone

Sign Into View Organizational & Contract Pricing

All Photos(1)

About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₀O₆

CAS Number:

491-70-3

Molecular Weight:

286.24

MDL number:

MFCD00017309

UNSPSC Code:

12352200

NACRES:

NA.77

Quality Level

100

Assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

yellow

solubility

aqueous base: 1.4 mg/mL
DMSO: 7 mg/mL
ethanol: soluble

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

InChI key

IQPNAANSBPBGFQ-UHFFFAOYSA-N

General description

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T1/2CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

Biochem/physiol Actions

Cell permeable: no

Primary Target
rat liver cytosolic glutathione S-transferase activity

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.

Other Notes

Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther.in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service