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Merck
CN

438075

Longdaysin

A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIα and CKIδ activities with moderate selectivity over Cdk7 and Erk2.

Synonym(s):

Longdaysin, 9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine, Casein Kinase I Inhibitor VII, Casein Kinase I Inhibitor VII, 9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine

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About This Item

Empirical Formula (Hill Notation):
C16H16F3N5
CAS Number:
1353867-91-0
Molecular Weight:
335.33
UNSPSC Code:
12352200
MDL number:
MFCD20527323

Key Documents

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assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

wet ice

Quality Level

100

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General description

A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIα and CKIδ activities (IC50 = 5.6 and 8.8 µM) with moderate selectivity over Cdk7 and Erk2 (IC50 = 29 and 52 µM). Shown to block CKIα/δ-mediated phosphorylation of PER1, a clock protein, (IC50 ~ 9 µM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~ 13 hrs at 10 µM) much more effectively than Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) and IC261 (Cat. No. 400090 ) and in larval zebra fish.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Hirota, T., et al. 2010. PLoS Biol.8, e1000559.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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