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Merck
CN

437694

Dihydro-DL-α-Lipoic Acid

≥95% (TLC), NO scavenger, liquid

Synonym(s):

DL-α-Lipoic Acid, Dihydro-, DHLA, Dihydrolipoic Acid, Thiocytic Acid, Dihydro-

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About This Item

Empirical Formula (Hill Notation):
C8H16O2S2
CAS Number:
462-20-4
Molecular Weight:
208.34
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
MFCD00166974

Key Documents

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Product Name

DL-α-Lipoic Acid, Dihydro-, An effective antioxidant.

SMILES string

SC(CCS)CCCCC(=O)O

InChI

1S/C8H16O2S2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H,9,10)

InChI key

IZFHEQBZOYJLPK-UHFFFAOYSA-N

assay

≥95% (TLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light yellow

solubility

ethanol: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: no
Primary Target
Scavenges hypochlorous acid, peroxyl, superoxide, hydroxyl, and nitric oxide radicals
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Irritant (B)

General description

An effective antioxidant. Scavenges hypochlorous acid, peroxyl, superoxide, hydroxyl, and nitric oxide radicals. Also exhibits prooxidant properties, as demonstrated by its ability to reduce iron ions and to generate reactive sulfur-containing radicals that can damage certain proteins, such as α1-antiproteinase and creatine kinase. DHLA has recently been shown to inhibit apoptosis in rat thymocytes induced by methylprednisolone and etoposide.

Other Notes

Packer, L., et al. 1997. Adv. Pharmacol. 38, 79.
Bustamante, J., et al. 1995. Free Radic. Biol. Med. 19, 339.
Scott, B.C., et al. 1994. Free Radic. Res. 20, 119.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

348.1 °F - Cleveland open cup

flash_point_c

175.6 °C - Cleveland open cup

Certificates of Analysis (COA)

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