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420203

Sigma-Aldrich

JMJD Histone Demethylase Inhibitor IV, Methylstat

The JMJD Histone Demethylase Inhibitor IV, Methylstat controls the biological activity of JMJD Histone Demethylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

JMJD Histone Demethylase Inhibitor IV, Methylstat, JHDM Inhibitor IV, ( E)-Methyl-4-(hydroxy(4-((4-(((naphthalen-1-ylcarbamoyl)oxy)methyl)benzyl)amino)butyl)amino)-4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, JHDM Inhibitor IV, (E)-Methyl-4-(hydroxy(4-((4-(((naphthalen-1-ylcarbamoyl)oxy)methyl)benzyl)amino)butyl)amino)-4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII

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About This Item

Empirical Formula (Hill Notation):
C28H31N3O6
CAS Number:
1310877-95-2
Molecular Weight:
505.56
MDL number:
MFCD22572723
UNSPSC Code:
12352200

Quality Level

100

Assay

≥96% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound (Cat. No. 420202) that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3 = 10.3 and 8.6 µM in KYSE150 cells, and 6.7 and 6.3 µM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2 µM.
A methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound (Cat. No. 420202) that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3 = 10.3 and 8.6 µM in KYSE150 cells, and 6.7 and 6.3 µM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2 µM.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Luo, X., et al. 2011. J. Am. Chem. Soc.133, 9451.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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