420136
JNK Inhibitor IX
The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Synonym(s):
JNK Inhibitor IX, N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide
Empirical Formula (Hill Notation):
C20H16N2OS · xH2O
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
tan
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23)
InChI key
WQGDQGAFSDMBLA-UHFFFAOYSA-N
General description
A thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC50 = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC50<5.0). In contrast, SP600125 offers little selectivity between JNK1 and JNK3 (pIC50 = 6.4 and 5.9, respectively) under the same assay conditions.
Biochem/physiol Actions
Cell permeable: no
Primary Target
JNK2 and JNK3
JNK2 and JNK3
Product competes with ATP.
Reversible: no
pIC50 = 6.5 and 6.7, against JNK2 and JNK3, respectively
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Angell, R.M., et al. 2007. Bioorg. Med. Chem. Lett.17, 1296.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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