420134
JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable
The JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Synonym(s):
JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable, H₂N-YGRKKRRQRRR-RPKRPTTLNLF-NH₂, TAT₃₈₋₄₈ -Truncated Inhibitor based on JNK-Interacting Protein 1
Empirical Formula (Hill Notation):
C125H220N52O27
Molecular Weight:
2883.42
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
solubility
water: 1 mg/mL
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
The non-permeant JNK inhibitor peptide TI-JIP153-163 (Cat. No. 420133) is made cell-permeable with an N-terminal TAT protein transduction domain sequence. Shown to offer neuroprotection in a rat ischemic brain injury model in in vivo.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
JNK
JNK
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Sequence
H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Guan, Q.H., et al. 2006. Neuroscience, 139, 609.
Barr, R.K., et al. 2004. J. Biol. Chem.279, 36327.
Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett.8, 550.
Barr, R.K., et al. 2002. J. Biol. Chem.277, 10987.
Barr, R.K., et al. 2004. J. Biol. Chem.279, 36327.
Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett.8, 550.
Barr, R.K., et al. 2002. J. Biol. Chem.277, 10987.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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