407317
Anti-Integrin β₆ Mouse mAb (442.5C4)
liquid, clone 442.5C4, Calbiochem®
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UNSPSC Code:
12352203
NACRES:
NA.43
Recommended Products
biological source
mouse
Quality Level
antibody form
ascites fluid
antibody product type
primary antibodies
clone
442.5C4, monoclonal
form
liquid
does not contain
preservative
species reactivity
human
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
isotype
IgG
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ITGB6(3694)
General description
Mouse monoclonal antibody supplied as undiluted ascites. Recognizes the β6 integrin chain.
Recognizes the β6 integrin chain.
This Anti-Integrin β₆ Mouse mAb (442.5C4) is validated for use in ELISA, FC, Immunoblotting, IP, Paraffin Sections for the detection of Integrin β₆.
Immunogen
Human
recombinant, human αvβ₆
Application
ELISA (see comments)
Flow Cytometry (1:50-1:100)
Immunoblotting (1:50-1:100)
Immunoprecipitation (1:50-1:100)
Paraffin Sections (1:50-1:100)
Flow Cytometry (1:50-1:100)
Immunoblotting (1:50-1:100)
Immunoprecipitation (1:50-1:100)
Paraffin Sections (1:50-1:100)
Warning
Toxicity: Standard Handling (A)
Physical form
Undiluted ascites.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Miller, L.A., et al. 2001. J. Histochem. Cytochem.49, 41.
Breuss, J.M., et al. 1995. J. Cell Sci.108, 2241.
Hynes, R.O. 1992. Cell.69, 11.
Albelda, S.M. and Buck, C.A. 1990. FASEB J.4, 2868.
Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol.3, 179.
Hynes, R.O. 1987. Cell.45, 549.
Breuss, J.M., et al. 1995. J. Cell Sci.108, 2241.
Hynes, R.O. 1992. Cell.69, 11.
Albelda, S.M. and Buck, C.A. 1990. FASEB J.4, 2868.
Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol.3, 179.
Hynes, R.O. 1987. Cell.45, 549.
This antibody has also been reported to work for ELISA. Variables associated with assay conditions will dictate the proper working dilution.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Ludmila Prudkin et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(5), 668-678 (2009-03-10)
Epithelial-to-mesenchymal transition is a process in which cells undergo a developmental switch from an epithelial to a mesenchymal phenotype. We investigated the role of this phenomenon in the pathogenesis and progression of adenocarcinoma and squamous cell carcinoma of the lung.
Johannes Notni et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 58(4), 671-677 (2016-12-17)
Expression of the cellular transmembrane receptor αvβ6 integrin is essentially restricted to malignant epithelial cells in carcinomas of a broad variety of lineages, whereas it is virtually absent in normal adult tissues. Thus, it is a highly attractive target for
EANM'16.
European journal of nuclear medicine and molecular imaging, 43(Suppl 1), 1-734 (2016-09-22)
Poster Presentations.
Journal of labelled compounds & radiopharmaceuticals, 60 Suppl 1, 111-640 (2017-05-16)
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