401484
IKK-2 Inhibitor IV
InSolution, ≥95%
Synonym(s):
InSolution IKK-2 Inhibitor IV
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About This Item
Empirical Formula (Hill Notation):
C12H10FN3O2S
Molecular Weight:
279.29
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥95% (HPLC)
form
liquid
potency
18 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
clear pale yellow
shipped in
wet ice
storage temp.
2-8°C
General description
IKK-2 Inhibitor IV (Cat. No. 401481) supplied in DMSO. A cell-permeable and potent inhibitor of IKK-2 (IC50 = 18 nM) that exhibits selectivity over IKK-1, JNK, and p38 MAPK. Inhibits TNF-α production in human monocytes (IC50 in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC50 = 100 nM). Shown to reduce paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg/kg).
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Physical form
A 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Flash Point(F)
(Dimethylsulfoxide)
Flash Point(C)
(Dimethylsulfoxide)
Certificates of Analysis (COA)
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