Skip to Content
Merck
CN

393204

4-Hydroxynonenal

≥98% (HPLC), liquid, lipid peroxidation marker, Calbiochem®

Synonym(s):

4-Hydroxynonenal

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C9H16O2
CAS Number:
75899-68-2
Molecular Weight:
156.22
MDL number:
MFCD00211020
UNSPSC Code:
12352114
NACRES:
NA.77

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

4-Hydroxynonenal, 4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.

SMILES string

OC(CCCCC)\C=C\C=O

InChI

1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+

InChI key

JVJFIQYAHPMBBX-FNORWQNLSA-N

description

RTECS - RA8510000

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

ethanol: 10 mg/mL

storage temp.

−70°C

Quality Level

100

Related Categories

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Supplied at 10 mg/ml in ethanol

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Biochem/physiol Actions

Primary Target
Na+, K+-ATPase activity
Product does not compete with ATP.
Target IC50: 120 µM against Na+, K+-ATPase activity

Disclaimer

Toxicity: Flammable (J)

General description

4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.
A major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca2+ and irreversibly inhibits Na+, K+-ATPase activity (IC50 = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).
A major aldehydic product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca2+. Irreversibly inhibits Na+-K+-ATPase activity (IC50 = 120 µM).

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Soh, Y., et al. 2000. Mol. Pharmacol.58, 535.
Carini, R., et al. 1996. Biochem. Biophys. Res. Commun.218, 772.
Li, L., et al. 1996. Toxicol.Appl. Pharmacol.139, 135.
Siems, W.G., et al. 1996. Free Radic. Res.20, 215.
Ullrich, O., et al. 1996. Free Radic. Res.24, 421.
van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
Esterbauer, H., et al. 1991. Free Radic. Biol. Med.11, 81.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

hcodes

H225,H319

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

57.2 °F - closed cup

flash_point_c

14 °C - closed cup

Regulatory Information

危险化学品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Miriam Hernández-Morales et al.
Cell reports, 30(10), 3250-3260 (2020-03-12)
One approach to magnetogenetics uses radiofrequency (RF) waves to activate transient receptor potential channels (TRPV1 and TRPV4) that are coupled to cellular ferritins. The mechanisms underlying this effect are unclear and controversial. Theoretical calculations suggest that the heat produced by
Jakob Morgenstern et al.
STAR protocols, 1(3), 100206-100206 (2020-12-31)
Aldo-keto reductases (AKRs) are responsible for the detoxification of harmful aldehydes. Due to the large number of isotypes, the physiological relevance of AKRs cannot be obtained using mRNA or protein quantification, but only through the use of enzymatic assays to

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service