382425
Trequinsin, Hydrochloride
Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC₅₀ = 300 pM) and platelet aggregation in vitro.
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Synonym(s):
Trequinsin, Hydrochloride, 9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725
Empirical Formula (Hill Notation):
C24H27N3O3 · xHCl
CAS Number:
Molecular Weight:
405.49 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
pale yellow
solubility
water: 500 μM
shipped in
ambient
storage temp.
10-30°C
InChI
1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H
InChI key
DTCZZBVPTHVXFA-UHFFFAOYSA-N
General description
Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
cGMP-inhibited phosphodiesterase
cGMP-inhibited phosphodiesterase
Product does not compete with ATP.
Reversible: no
Target IC50: 300 pM against cGMP-inhibited phosphodiesterase
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Spina, D., et al. 1998. Life Sci. 62, 953.
Pillai, R., et al. 1994. J. Biol. Chem.269, 30676.
Tang, K.M., et al. 1994. Eur. J. Pharmacol.268, 105.
Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.
DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
Ruppert, D., and Weithmann, K.U. 1982. Life Sci.31, 2037.
Pillai, R., et al. 1994. J. Biol. Chem.269, 30676.
Tang, K.M., et al. 1994. Eur. J. Pharmacol.268, 105.
Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.
DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
Ruppert, D., and Weithmann, K.U. 1982. Life Sci.31, 2037.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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