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Sigma-Aldrich

HDAC Inhibitor XIX, Compound 2

The HDAC Inhibitor XIX, Compound 2, also referenced under CAS 6953-61-3, controls the biological activity of HDAC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

HDAC Inhibitor XIX, Compound 2, 1-Naphthohydroxamic Acid, N-Hydroxynaphthalene-1-carboxamide, Histone Deacetylase Inhibitor XIX

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About This Item

Empirical Formula (Hill Notation):
C11H9NO2
CAS Number:
6953-61-3
Molecular Weight:
187.19
MDL number:
MFCD00059546
UNSPSC Code:
12352200

Quality Level

100

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)

InChI key

JRZGPWOEHDOVMC-UHFFFAOYSA-N

General description

A cell-permeable aryl-hydroxamate compound that selectively inhibits the activity of HDAC8 (IC50 = 14 µM) over class I HDAC1 and class II HDAC6 (IC50 >100 µM) without affecting the overall H4 acetylation level in BE(2)-C cultures even at concentrations as high as 20 µM. HDAC8 downregulation by either Compound 2 (10 to 40 µM) or siRNA in neuroblastoma cultures is reported to result in growth inhibition accompanied by neurite-like morphological changes. Compound 2 effectively enhances tubulin acetylation in both HeLa and HEK 293 cultures, indicating that alternative cellular enzyme(s) other than HDAC6 can be targeted for regulating tubulin acetylation.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Oehme, I., et al. 2009. Expert Opin. Investig. Drugs18, 1605.
Oehme, I., et al. 2009. Clin. Cancer Res.15, 91.
KrennHrubec, K., et al. 2007. Bioorg. Med. Chem. Lett.17, 2874.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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