Skip to Content

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
All Photos(1)

Key Documents

View All Documentation

382110

Sigma-Aldrich

Histone Acetyltransferase Inhibitor II

The Histone Acetyltransferase Inhibitor II, also referenced under CAS 932749-62-7, controls the biological activity of Histone Acetyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

Histone Acetyltransferase Inhibitor II, 2,6- bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I, 2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I

Sign Into View Organizational & Contract Pricing

Select a Size

100 ML
¥2,335.07

¥2,335.07

Please contact Customer Service for Availability
Sign In for Best Price
All Photos(1)

Select a Size

Change View
100 ML
¥2,335.07

About This Item

Empirical Formula (Hill Notation):
C20H16Br2O3
CAS Number:
932749-62-7
Molecular Weight:
464.15
MDL number:
MFCD11655778
UNSPSC Code:
12352200
NACRES:
NA.77

¥2,335.07

Please contact Customer Service for Availability
Sign In for Best Price

Quality Level

100

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

ethanol: 10 mg/mL
DMSO: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Brc1c(ccc(c1)\C=C2/CCC\C(=C/c3cc(c(cc3)O)Br)\C/2=O)O

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
T74089036090358
Borate buffer suitable for HPLC, LiChropur™, 0.127-0.140 M

89273

Borate buffer

Triethylammonium bicarbonate buffer 1.0 M, pH 8.5±0.1

T7408

Triethylammonium bicarbonate buffer

Triethylammonium bicarbonate buffer volatile buffer, ~1.0 M in H2O

90360

Triethylammonium bicarbonate buffer

Triethylammonium acetate buffer volatile buffer, ~1.0 M in H2O

90358

Triethylammonium acetate buffer

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

-

technique(s)

electrophoresis: suitable

concentration

0.127-0.140 M

concentration

1.0 M

concentration

~1.0 M in H2O

concentration

1 M, ~1.0 M in H2O

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

form

liquid

form

liquid

form

liquid

form

liquid

density

1.000-1.020 g/mL at 20 °C

density

1.02 g/mL at 25 °C (lit.)

density

1.018 g/mL at 20 °C

density

1.002 g/mL at 20 °C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC50 = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC50 ≤ 40 µM) and induce chromatin condensation in HeLa cells.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month.

Other Notes

Costi, R., et al. 2007. J. Med. Chem.50, 1973.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

    • Certificates of Analysis (COA)

    Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Lingling Meng et al.
    Heliyon, 10(6), e27045-e27045 (2024-03-19)
    Imbalances between Bcl-2 and caspase-3 are significant evidence of apoptosis, which is considered an influential factor in rapidly occurring neuronal cell death and the decline of neurological function after stroke. Studies have shown that acupuncture can reduce poststroke brain cell

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service